Pharmacotherapy Database

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Description: PharmacotherapyDB is a catalog of medical indications between small molecule compounds and complex human diseases. We created the resource as part of our network-based drug repurposing project. However, PharmacotherapyDB is designed to be broadly applicable as a gold standard of drug indications for computational approaches. The catalog adheres to pathophysiological principals first. Therefore, the catalog includes indications with a poor risk–benefit ratio that are rarely used in the modern clinic.

PharmacotherapyDB differentiates between disease-modifying and symptomatic treatments. Each indication has been reviewed by multiple physicians. We use standardized vocabularies (the Disease Ontology and DrugBank) to facilitate data integration.

Indications were classified by physician curators into three categories:

DM -- disease modifying SYM -- symptomatic NOT -- non-indication This initial release contains 97 diseases and 601 drugs. Between these drug–disease pairs, there are 755 disease-modifying therapies, 390 symptomatic therapies, and 243 non-indications. Read more about the initial release on Thinklab. The catalog data is available in catalog and on figshare.

• Technical Guide to Pharmacotherapy DB -

All original content in this repository is released under CC0. Please also abide by the licenses of the sources if using their data. The Disease Ontology is released under CC BY 3.0. DrugBank requires permission for commercial reuse. LabaledIn data is public domain. MEDI and PREDICT data are CC BY-NC-SA 3.0. EHRLink data was retrieved from PubMed Central and does not specify a license.

Example edge:

URL: https://github.com/dhimmel/indications