gomelt is a golang implementation of DNA oligo melting temperature calculations based on the Nearest-neighbor method.
Specific information for this can be found on this Wikipedia page.
$ go get github.com/mimikwang/gomelt
Calculate melting temperature:
package main
import (
"fmt"
"github.com/mimikwang/gomelt"
)
func main() {
// Set up thermodynamics parameters
parameters := gomelt.Params{
Monovalent: 50.0,
Divalent: 1.5,
Dntp: 0.2,
Dna: 200.0,
T: 37.0,
}
// Calculate melting thermodynamics
result, _ := gomelt.MeltingTemp("AAAGGCCTT", parameters)
fmt.Println(result.Tm)
// 20.24
fmt.Println(result.Dh)
// -59.6
fmt.Println(result.Ds)
// -169.74
fmt.Println(result.Dg)
// -6.96
}