cRF and matchability calculator

Data sources

10,000 donors used int the NHSBT-ODT cRF calculator

Caclulations

Sensitisation:

• cRF = calculated Reaction Frequency

• D_i = ABO identical and HLA-incompatible donors

• D_all = all ABO-identical donors

  $cRF = \frac{Di}{Dall} \times 100\%$

Matchability:

• D_fm = the number of ABO identical, HLA-compatible and favourably matched donors
• Assign a matchability point according to the following matchability banding:

BG	1	2	3	4	5	6	7	8	9	10
A	360	279	228	178	146	115	87	63	19	0
B	70	54	42	35	29	24	19	14	6	0
O	405	311	247	193	157	128	103	74	34	0
AB	23	14	10	8	6	3		2		0

NB: The bandings changes at each release of the official calculator

How to deploy this app

Docker image from Dockerfile

/* Building Docker Image */
docker build . -t matchbox:latest

/* Running Docker container mapping port 80 to external port 4000 */
docker run -d -p 4000:80 --restart always matchbox:latest

Docker image from Docker Hub

/* Pulling the image */
docker pull machnine/matchbox:latest

/* Running Docker container mapping port 80 to external port 4000 */
docker run -d -p 4000:80 --restart always machnine/matchbox:latest

API endpoint

This app has one GET endpoint /calc/ which accepts the following queries:

    GET /calc/?bg=O&specs=A2,A11,B64,CW15,DR15,DQ6,DPB2&recip_hla=B7,B18,DR9,DR2&donor_set=0 HTTP/1.1

• bg: blood group e.g. "A"
• specs: antibody specs e.g. "A1,B2,DR1"
• donor_set: all donors [0, default] or only donors with HLA-DPB1 types [1]
• recip_hla: recipient HLA-B and DR type (broad) e.g. "B7,B8,DR9"

Google Analytics

To use Google Analytics, add the environment variable at docker run

docker run -d -p 4000:80 -e GA_TRACKING_ID=G-YOUR_TRAKCKING_ID --restart always matchbox:latest