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During the transition to GATK4 the method for producing a genotyped vcf was changed. With GATK4, the HaplotypeCaller tool produces the genotyped vcf. This is happens when the --emit-ref-confidence option is set to NONE.
With GATK3, the HaplotypeCaller tool produced genome vcfs(gvcfs). These gvcfs were genotyped in the next step with GenotypeGVCFs. This allowed the pipeline to produce gvcfs and a final genotyped vcf.
After discussing with Tom(#1037) I think the method used with GATK3 should be the default for the germline pipelines. Might be best to avoid merging #1037 and make a new PR adding the GenotypeGVCFs step.
steps:
add back in the GenotypeGVCFs step
update/add emit_reference_confidence enum input
remove the NONE option for pipeline inputs since the GenotypeGVCFs step will be used
add gvcf outputs
add documentation
The text was updated successfully, but these errors were encountered:
During the transition to GATK4 the method for producing a genotyped vcf was changed. With GATK4, the HaplotypeCaller tool produces the genotyped vcf. This is happens when the
--emit-ref-confidence
option is set toNONE
.With GATK3, the HaplotypeCaller tool produced genome vcfs(gvcfs). These gvcfs were genotyped in the next step with GenotypeGVCFs. This allowed the pipeline to produce gvcfs and a final genotyped vcf.
After discussing with Tom(#1037) I think the method used with GATK3 should be the default for the germline pipelines. Might be best to avoid merging #1037 and make a new PR adding the GenotypeGVCFs step.
steps:
emit_reference_confidence
enum inputremove the
NONE
option for pipeline inputs since the GenotypeGVCFs step will be usedThe text was updated successfully, but these errors were encountered: