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|**Enzyme Commission (EC) enzyme numbers** <br>[Enzyme Commission](https://www.qmul.ac.uk/sbcs/iubmb/){:target="blank"}; contact: [GO Ontology editors](mailto:[email protected]) <br> *Constructed and maintained in the [GO ontology file](/docs/download-ontology/) by GO editorial staff* <br>Citation: Hill DP, Davis AP, Richardson JE, Corradi JP, Ringwald M, Eppig JT, Blake JA. Program description: Strategies for biological annotation of mammalian systems: implementing gene ontologies in mouse genome informatics. Genomics. May 2001;74(1):121–8. <br>[ [PMID:11374909](http://www.ncbi.nlm.nih.gov/pubmed/11374909){:target="blank"} \| [doi:10.1006/geno.2001.6513](http://dx.doi.org/10.1006/geno.2001.6513){:target="blank"} ]|Continuous | [txt](http://geneontology.org/external2go/ec2go)| | ||
|**KEGG pathways and reactions**<br> [Kyoto Encyclopaedia of Genes and Genomes](http://www.genome.jp/kegg/){:target="blank"}<br> *Constructed and maintained by Amelia Ireland and a script*|Continuous | [txt](http://geneontology.org/external2go/kegg2go)| | ||
|**MetaCyc pathways and reactions**<br> [MetaCyc](http://metacyc.org/){:target="blank"}; contact: [GO Ontology editors](mailto:[email protected]) <br> *Constructed and maintained in the [GO ontology file](/docs/download-ontology/) by GO editorial staff*|Continuous |[txt](http://geneontology.org/external2go/metacyc2go)| | ||
|**MIPS FunCat**<br>[MIPS Functional Catalogue (FunCat)](http://mips.gsf.de/funcatDB/){:target="blank"}<br> *Constructed by Michael Ashburner and Midori Harris*|Continuous| [txt](http://geneontology.org/external2go/mips2go)| | ||
|**MIPS FunCat**<br>[MIPS Functional Catalogue (FunCat)](http://mips.gsf.de/funcatDB/){:target="blank"}<br> *Constructed by Michael Ashburner and Midori Harris*|Continuous| no link <!--[txt](http://geneontology.org/external2go/mips2go)-->| | ||
|**Reactome events and catalyst activities**<br> [Reactome](http://www.reactome.org/){:target="blank"}<br> *Constructed by Reactome curators and maintained in the [GO ontology file](/docs/download-ontology/) by GO editorial staff*|Continuous | [txt](http://geneontology.org/external2go/reactome2go)| | ||
|**Rhea Annotated Reactions Database**<br> [Rhea](http://www.ebi.ac.uk/rhea/){:target="blank"}<br> *Constructed and maintained by Amelia Ireland and a script*|Continuous | [txt](http://geneontology.org/external2go/rhea2go)| | ||
|**EAWAG-BBD enzyme IDs**<br> [Swiss Federal Institute of Aquatic Science and Technology Biocatalysis/Biodegradation Database (EAWAG-BBD)](http://eawag-bbd.ethz.ch/aboutBBD.html){:target="blank"}; contact: [GO Ontology editors](mailto:[email protected])<br> *Maintained in the [GO ontology file](/docs/download-ontology/) by GO editorial staff*|Continuous | [txt](http://geneontology.org/external2go/um-bbd_enzymeid2go)| | ||
|**EAWAG-BBD pathway IDs**<br> [Swiss Federal Institute of Aquatic Science and Technology Biocatalysis/Biodegradation Database (EAWAG-BBD)](http://eawag-bbd.ethz.ch/aboutBBD.html){:target="blank"}; contact: [GO Ontology editors](mailto:[email protected])<br> *Maintained in the [GO ontology file](/docs/download-ontology/) by GO editorial staff*|Continuous |[txt](http://geneontology.org/external2go/um-bbd_pathwayid2go)| | ||
|**EAWAG-BBD reaction IDs**<br> [Swiss Federal Institute of Aquatic Science and Technology Biocatalysis/Biodegradation Database (EAWAG-BBD)](http://eawag-bbd.ethz.ch/aboutBBD.html){:target="blank"}; contact: [GO Ontology editors](mailto:[email protected])<br> *Maintained in the [GO ontology file](/docs/download-ontology/) by GO editorial staff*|Continuous |[txt](http://geneontology.org/external2go/um-bbd_reactionid2go)| | ||
|**EAWAG-BBD reaction IDs**<br> [Swiss Federal Institute of Aquatic Science and Technology Biocatalysis/Biodegradation Database (EAWAG-BBD)](http://eawag-bbd.ethz.ch/aboutBBD.html){:target="blank"}; contact: [GO Ontology editors](mailto:[email protected])<br> *Maintained in the [GO ontology file](/docs/download-ontology/) by GO editorial staff*|Continuous | no link <!--[txt](http://geneontology.org/external2go/um-bbd_reactionid2go)-->| | ||
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## Mappings files provided by external groups | ||
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|Mapping |Last update | Download| | ||
|--------|------------|---------| | ||
|**COG functional categories** <br>[Clusters of Orthologous Groups (COG)](https://www.ncbi.nlm.nih.gov/COG/index.html){:target="blank"}<br> *Constructed by Michael Ashburner and Jane Lomax* |June 2004 | [txt](http://geneontology.org/external2go/cog2go)| | ||
|**Expressed Gene Anatomy Database (EGAD)** <br> *Constructed by Michael Ashburner* | Oct 2000 | [txt](http://geneontology.org/external2go/egad2go)| | ||
|**E. coli Genome and Proteome functional categories (GenProtEC)** <br>*Constructed by Heather Butler and Michael Ashburner*|Dec 2000 |[txt](http://geneontology.org/external2go/genprotec2go)| | ||
|**COG functional categories** <br>[Clusters of Orthologous Groups (COG)](https://www.ncbi.nlm.nih.gov/COG/index.html){:target="blank"}<br> *Constructed by Michael Ashburner and Jane Lomax* |June 2004 | no link <!--[txt](http://geneontology.org/external2go/cog2go)-->| | ||
|**Expressed Gene Anatomy Database (EGAD)** <br> *Constructed by Michael Ashburner* | Oct 2000 | no link <!--[txt](http://geneontology.org/external2go/egad2go)-->| | ||
|**E. coli Genome and Proteome functional categories (GenProtEC)** <br>*Constructed by Heather Butler and Michael Ashburner*|Dec 2000 |no link <!--[txt](http://geneontology.org/external2go/genprotec2go)-->| | ||
|**HAMAP families** <br>[High-Quality Automated and Manual Annotation of Microbial Proteomes (HAMAP)](http://www.expasy.org/sprot/hamap/){:target="blank"}; contact: [UniProtKB-GOA team](mailto:[email protected]) <br> *Mapping generated by the HAMAP and UniProtKB UniProtKB-GOA teams* <br> Citation: Lima T, Auchincloss AH, Coudert E, Keller G, Michoud K, Rivoire C, Bulliard V, de Castro E, Lachaize C, Baratin D, Phan I, Bougueleret L, Bairoch A. HAMAP: a database of completely sequenced microbial proteome sets and manually curated microbial protein families in UniProtKB/Swiss-Prot. Nucleic Acids Res.. Jan 2009;37(Database issue):D471–8. <br>[ [PMID:18849571](http://www.ncbi.nlm.nih.gov/pubmed/18849571){:target="blank"} \| [doi:10.1093/nar/gkn661](http://dx.doi.org/10.1093/nar/gkn661){:target="blank"} ]| Monthly | [txt](http://geneontology.org/external2go/hamap2go) | | ||
|**InterPro protein families, domains and functional sites**<br>[InterPro](http://www.ebi.ac.uk/interpro/){:target="blank"}; contact: [InterPro team](mailto:[email protected])<br>Citation: Hunter S, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Das U, Daugherty L, Duquenne L, Finn RD, Gough J, Haft D, Hulo N, Kahn D, Kelly E, Laugraud A, Letunic I, Lonsdale D, Lopez R, Madera M, Maslen J, McAnulla C, McDowall J, Mistry J, Mitchell A, Mulder N, Natale D, Orengo C, Quinn AF, Selengut JD, Sigrist CJ, Thimma M, Thomas PD, Valentin F, Wilson D, Wu CH, Yeats C. InterPro: the integrative protein signature database. Nucleic Acids Res.. Jan 2009;37(Database issue):D211–5. <br>[ [PMID:18940856](http://www.ncbi.nlm.nih.gov/pubmed/18940856){:target="blank"} \| [doi:10.1093/nar/gkn785](http://dx.doi.org/10.1093/nar/gkn785){:target="blank"} ]|Monthly | [txt](http://geneontology.org/external2go/interpro2go)| | ||
|**MultiFun cell function assignment schema classifications**<br> *Constructed by Michael Ashburner, Jane Lomax and Margrethe Hauge Serres*|Dec 2005 | [txt](http://geneontology.org/external2go/multifun2go)| | ||
|**MultiFun cell function assignment schema classifications**<br> *Constructed by Michael Ashburner, Jane Lomax and Margrethe Hauge Serres*|Dec 2005 | no link <!--[txt](http://geneontology.org/external2go/multifun2go)-->| | ||
|**Pfam domains**<br> [Pfam](http://pfam.xfam.org/){:target="blank"}; contact: [InterPro team](mailto:[email protected])<br> *This mapping is generated from data supplied by [InterPro](http://www.ebi.ac.uk/interpro/){:target="blank"} for the InterPro2GO mapping* <br> Citation: Hunter S, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Das U, Daugherty L, Duquenne L, Finn RD, Gough J, Haft D, Hulo N, Kahn D, Kelly E, Laugraud A, Letunic I, Lonsdale D, Lopez R, Madera M, Maslen J, McAnulla C, McDowall J, Mistry J, Mitchell A, Mulder N, Natale D, Orengo C, Quinn AF, Selengut JD, Sigrist CJ, Thimma M, Thomas PD, Valentin F, Wilson D, Wu CH, Yeats C. InterPro: the integrative protein signature database. Nucleic Acids Res.. Jan 2009;37(Database issue):D211–5. <br>[ [PMID:18940856](http://www.ncbi.nlm.nih.gov/pubmed/18940856){:target="blank"} \| [doi:10.1093/nar/gkn785](http://dx.doi.org/10.1093/nar/gkn785){:target="blank"} ]|Monthly |[txt](http://geneontology.org/external2go/pfam2go)| | ||
|**PIRSF protein superfamilies**<br> [PIRSF](http://pir.georgetown.edu/pirwww/dbinfo/pirsf.shtml){:target="blank"}; contact: [InterPro team](mailto:[email protected])<br> *This mapping is generated from data supplied by [InterPro](http://www.ebi.ac.uk/interpro/){:target="blank"} for the InterPro2GO mapping* <br> Citation: Hunter S, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Das U, Daugherty L, Duquenne L, Finn RD, Gough J, Haft D, Hulo N, Kahn D, Kelly E, Laugraud A, Letunic I, Lonsdale D, Lopez R, Madera M, Maslen J, McAnulla C, McDowall J, Mistry J, Mitchell A, Mulder N, Natale D, Orengo C, Quinn AF, Selengut JD, Sigrist CJ, Thimma M, Thomas PD, Valentin F, Wilson D, Wu CH, Yeats C. InterPro: the integrative protein signature database. Nucleic Acids Res.. Jan 2009;37(Database issue):D211–5. <br>[ [PMID:18940856](http://www.ncbi.nlm.nih.gov/pubmed/18940856){:target="blank"} \| [doi:10.1093/nar/gkn785](http://dx.doi.org/10.1093/nar/gkn785){:target="blank"} ]| Monthly | [txt](http://geneontology.org/external2go/pirsf2go)| | ||
|**PRINTS domains**<br> [PRINTS](http://www.bioinf.manchester.ac.uk/dbbrowser/PRINTS/){:target="blank"}; contact: [InterPro team](mailto:[email protected])<br> *This mapping is generated from data supplied by [InterPro](http://www.ebi.ac.uk/interpro/){:target="blank"} for the InterPro2GO mapping* <br> Citation: Hunter S, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Das U, Daugherty L, Duquenne L, Finn RD, Gough J, Haft D, Hulo N, Kahn D, Kelly E, Laugraud A, Letunic I, Lonsdale D, Lopez R, Madera M, Maslen J, McAnulla C, McDowall J, Mistry J, Mitchell A, Mulder N, Natale D, Orengo C, Quinn AF, Selengut JD, Sigrist CJ, Thimma M, Thomas PD, Valentin F, Wilson D, Wu CH, Yeats C. InterPro: the integrative protein signature database. Nucleic Acids Res.. Jan 2009;37(Database issue):D211–5. <br>[ [PMID:18940856](http://www.ncbi.nlm.nih.gov/pubmed/18940856){:target="blank"} \| [doi:10.1093/nar/gkn785](http://dx.doi.org/10.1093/nar/gkn785){:target="blank"} ]| Monthly | [txt](http://geneontology.org/external2go/prints2go)| | ||
|**ProDom domains** <br> [ProDom](http://prodom.prabi.fr/prodom/current/html/home.php){:target="blank"}; contact: [InterPro team](mailto:[email protected])<br> *This mapping is generated from data supplied by [InterPro](http://www.ebi.ac.uk/interpro/){:target="blank"} for the InterPro2GO mapping* <br> Citation: Hunter S, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Das U, Daugherty L, Duquenne L, Finn RD, Gough J, Haft D, Hulo N, Kahn D, Kelly E, Laugraud A, Letunic I, Lonsdale D, Lopez R, Madera M, Maslen J, McAnulla C, McDowall J, Mistry J, Mitchell A, Mulder N, Natale D, Orengo C, Quinn AF, Selengut JD, Sigrist CJ, Thimma M, Thomas PD, Valentin F, Wilson D, Wu CH, Yeats C. InterPro: the integrative protein signature database. Nucleic Acids Res.. Jan 2009;37(Database issue):D211–5. <br>[ [PMID:18940856](http://www.ncbi.nlm.nih.gov/pubmed/18940856){:target="blank"} \| [doi:10.1093/nar/gkn785](http://dx.doi.org/10.1093/nar/gkn785){:target="blank"} ]|Monthly | [txt](http://geneontology.org/external2go/prodom2go)| | ||
|**ProSite domains**<br> [ProSite](http://www.expasy.ch/prosite/){:target="blank"}; contact: [InterPro team](mailto:[email protected])<br> *This mapping is generated from data supplied by [InterPro](http://www.ebi.ac.uk/interpro/) for the InterPro2GO mapping*<br>Citation: Hunter S, Apweiler R, Attwood TK, Bairoch A, Bateman A, Binns D, Bork P, Das U, Daugherty L, Duquenne L, Finn RD, Gough J, Haft D, Hulo N, Kahn D, Kelly E, Laugraud A, Letunic I, Lonsdale D, Lopez R, Madera M, Maslen J, McAnulla C, McDowall J, Mistry J, Mitchell A, Mulder N, Natale D, Orengo C, Quinn AF, Selengut JD, Sigrist CJ, Thimma M, Thomas PD, Valentin F, Wilson D, Wu CH, Yeats C. InterPro: the integrative protein signature database. Nucleic Acids Res.. Jan 2009;37(Database issue):D211–5. <br>[ [PMID:18940856](http://www.ncbi.nlm.nih.gov/pubmed/18940856){:target="blank"} \| [doi:10.1093/nar/gkn785](http://dx.doi.org/10.1093/nar/gkn785){:target="blank"} ]|Monthly |[txt](http://geneontology.org/external2go/prosite2go)| | ||
|**Rfam RNA families**<br> [Rfam](http://rfam.xfam.org/){:target="blank"}<br> *Constructed and maintained by Sam Griffiths-Jones and Jennifer Daub*|May 2006 |[txt](http://geneontology.org/external2go/rfam2go)| | ||
|**SMART domains**<br> [SMART](http://smart.embl-heidelberg.de/){:target="blank"}; contact: [InterPro team](mailto:[email protected])<br> *This mapping is generated from data supplied by [InterPro](http://www.ebi.ac.uk/interpro/){:target="blank"} for the InterPro2GO mapping*<br>Citation:Letunic I, Bork P; 20 years of the SMART protein domain annotation resource. Nucleic Acids Res.. Jan 2018;46(D1):D493–D496. <br> [ [PMID:29040681](http://www.ncbi.nlm.nih.gov/pubmed/29040681){:target="blank"} \| [doi.org/10.1093/nar/gkx922]( https://doi.org/10.1093/nar/gkx922){:target="blank"} ]|Monthly | [txt](http://geneontology.org/external2go/smart2go)| | ||
|**JCVI (TIGRFAM) protein families**<br>[JCVI (TIGRFAM) protein families](https://www.jcvi.org/publications/tigrfams-protein-family-resource-functional-identification-proteins){:target="blank"}<br>*Constructed by Michelle Gwinn and other TIGR staff*|Monthly | [txt](http://geneontology.org/external2go/tigrfams2go)| | ||
|**JCVI roles**<br>[JCVI roles](https://www.jcvi.org/){:target="blank"}<br> *Constructed by Michael Ashburner*|Jan 2004 |[txt](http://geneontology.org/external2go/tigr2go)| | ||
|**JCVI (TIGRFAM) protein families**<br>[JCVI (TIGRFAM) protein families](https://www.jcvi.org/publications/tigrfams-protein-family-resource-functional-identification-proteins){:target="blank"}<br>*Constructed by Michelle Gwinn and other TIGR staff*|Monthly | no link <!--[txt](http://geneontology.org/external2go/tigrfams2go)-->| | ||
|**JCVI roles**<br>[JCVI roles](https://www.jcvi.org/){:target="blank"}<br> *Constructed by Michael Ashburner*|Jan 2004 | no link <!--[txt](http://geneontology.org/external2go/tigr2go)-->| | ||
|**UniProt Knowledgebase**<br> Mapping of GO terms to UniProt Knowledgebase keywords. <br> *This mapping is generated by the UniProtKB and UniProtKB-GOA teams [was SwissProt keyword]* <br>[UniProt](http://www.uniprot.org/){:target="blank"}; contact: [UniProtKB-GOA team](mailto:[email protected]) <br> Citation: Huntley RP, Sawford T, Mutowo-Meullenet P, Shypitsyna A, Bonilla C, Martin MJ, O’Donovan C. The GOA database: gene Ontology annotation updates for 2015. Nucleic Acids Res.. Jan 2015;43(Database issue):D1057–1063. <br>[ [PMID:25378336](https://www.ncbi.nlm.nih.gov/pubmed/25378336){:target="blank"} \| [doi:10.1093/nar/gku1113](http://dx.doi.org/10.1093/nar/gku1113){:target="blank"} ]|Monthly | [txt](http://geneontology.org/external2go/uniprotkb_kw2go)| | ||
|**UniProt subcellular location**<br> [UniProt](http://www.uniprot.org/){:target="blank"}; contact: [UniProtKB-GOA team](mailto:[email protected]) <br>Citation: Huntley RP, Sawford T, Mutowo-Meullenet P, Shypitsyna A, Bonilla C, Martin MJ, O’Donovan C. The GOA database: gene Ontology annotation updates for 2015. Nucleic Acids Res.. Jan 2015;43(Database issue):D1057–1063. <br>[ [PMID:25378336](https://www.ncbi.nlm.nih.gov/pubmed/25378336){:target="blank"} \| [doi:10.1093/nar/gku1113](http://dx.doi.org/10.1093/nar/gku1113){:target="blank"} ]| Monthly | [txt](http://geneontology.org/external2go/uniprotkb_sl2go)| | ||
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