BioGears 6.3.0

What's new in ver 6.3 (March 1, 2018)

The latest deployment includes the following notable updates:

• General bug fixes, system improvements, and tools/solver improvements
• Fasciculation patient event flags
• Updated sweat methodology (fixes to ions lost in sweat)
• Updated substance and compound infusion functionality
  • Added Ringers lactate and updated
  • Saline compound ion concentrations corrected
  • Hardened implementation
• MuscleMass new patient data request
  • Muscle catabolism patient flag
• Added dehydration condition
  • Implemented as scalar 0to1 representing fractional total body water lost
  • Fluid removed from patient compartments
  • Updated patient flag for event and track body weight change (validated)
  • Added totalbodyfluidVolume as data request
  • Updated patient weight as a function of condition
• Added starvation condition
  • TimeSinceMeal determines how long since the patient's last meal
  • Scales internal nutrient storages from validated starvation data
  • Removed ConsumeMeal condition, now replaced by starvation condition
  • Validated blood concentrations for ketones, glucose, and amino acids
  • Updated patient weight as a function of condition
• Intracellular ion transport
  • Model uses membrane potential (see @ref TissueMethodology for details)
  • Michaelis coefficient could support more ion regulation in the future
  • Gated ion transport allows for differences between intra/extracellular spaces
• COPD now supports elevated anaerobic metabolism
• Ion transport model in the small intestine
• Updated drug library so all drugs support an effects site transport rate
• Diabetes type 1 and type 2 conditions
  • insulin resistance and insulin production effects
• Hemorrhage action now initialized with a 0-1 severity and a location (MCIS SDK example still exists)
• New drug Vasopressin
• New drug classifications in the CDM for better grouping in-code
  • Include anesthetic, sedative, opioid, and reversal agent
  • More grouping in future work

6.2.0-beta

What's new in version 6.2 (September 28, 2017)

The latest deployment includes the following notable updates:

• General bug fixes, system improvements, and tools/solver improvements
• Intoxication model for Morphine
  • Effects site concentration to allow for delayed PD reactions
  • Central nervous modifier to model depressed feedback mechanisms
  • Noloxone reversal agent model
• New Hemorrhage model
  • MCIS support for combat injury coding
  • Location and severity can be flagged through MCIS
  • Resistance paths handle bleed out to simulate more realistic flow behavior
• Glucagon hormone
• New nutrient kinetics model
  • New metabolic production and consumption method
  • Protein storage and release model (amino acids in muscle)
  • Fat storage and release model
  • Interactions with the Hepatic system
• New Hepatic system
  • Maintains blood glucose from other substances like lactate through new gluconeogenesis method
  • Lipogenesis method generates triacylglycerol due to excess glucose and amino acid
  • Glycogenesis and glycogenolysis to maintain blood glucose levels
• Updated exercise model
  • Coupled to nutrient kinetic handling and metabolic need
• Updated diffusion method
• New Gastrointestinal model
  • Enzyme kinetics determine digestion of nutrients
  • Absorption facilitated through sodium co-transporter
  • Gastric secretion function allows for bile formation in chyme
• Desflurane update and fix

6.1.1-beta

Added URL to project.

6.1.0-beta

Added URL to project.

6.0.1-beta

Initial commit

5.1.0-beta

Initial commit

5.0.0-beta

Initial commit

4.0.0-beta.4700

Initial commit

3.0.0-alpha.4000

Initial commit

2.0.0-alpha.3400

Initial commit