Bioinformatics data analysis code accompanying: Taylor, J.D., Barrett, N., Martinez Cuesta, S. et al. Targeted protein degradation using chimeric human E2 ubiquitin-conjugating enzymes. Commun Biol 7, 1179 (2024). https://doi.org/10.1038/s42003-024-06803-4

Software requirements:

• R 3.6.0 with libraries:
  • devtools 2.3.2
  • tidyverse 1.3.0
  • yaml 2.2.1
  • data.table 1.13.2
  • limma 3.42.2
  • ggplot2 3.3.2
  • ggrepel 0.9.1
  • VennDiagram 1.6.20
  • (data preparation prior to differential expression analysis was performed using an in-house code)

To reproduce the data analyses, figures and tables in the paper, install the software requirements and run code.md