diff --git a/prereq.txt b/prereq.txt
index 75d0c81e..2d6fae3f 100644
--- a/prereq.txt
+++ b/prereq.txt
@@ -1,4 +1,4 @@
 numpy>=1.20
-torch>=2.1, <2.3 # Max due to tsai
-tsai
+torch>=2.1 # Min due to opacus, tsai 0.4.1+ supports latest PyTorch
+tsai>=0.4.1
 wheel>=0.40
diff --git a/setup.cfg b/setup.cfg
index e4623326..e69d8171 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -34,12 +34,12 @@ python_requires = >=3.9
 install_requires =
     importlib-metadata
     pandas>=2.1 # min due to lifelines
-    torch>=2.1, <2.3 # Max due to tsai, min due to opacus
+    torch>=2.3 # Min due to opacus, tsai 0.4.1+ supports latest PyTorch
     scikit-learn>=1.2
     nflows>=0.14
-    numpy>=1.20, <2.0
+    numpy>=1.20, <2.0 # max due to lifelines 0.29.0 requirement
     lifelines>=0.29.0, <0.30.0 # max due to xgbse
-    opacus>=1.3, <1.5.4 # 1.5.4 introduces RMSNorm error
+    opacus>=1.5.4 # RMSNorm support required for PyTorch 2.x compatibility
     networkx>2.0,<3.0
     decaf-synthetic-data>=0.1.7
     optuna>=3.1
@@ -55,17 +55,17 @@ install_requires =
     pgmpy<1.0
     redis
     pycox
-    xgbse>=0.3.1
+    xgbse==0.3.3
     pykeops
     fflows
     monai
-    tsai; python_version>"3.7"
+    tsai>=0.4.1; python_version>"3.7"
     be-great>=0.0.5;python_version>="3.9"
     arfpy
-    fastcore<1.8 # Required by breaking change in fastai 2.8 which is needed by tsai
-    fastai<2.8 # Required by breaking change in fastai 2.8 which is needed by tsai
-    transformers<4.33.0 # Required by great plugin while tranformers >4.33.0 is not compatible with torch <2.5
-    accelerate<0.20.4 # Required for transformers <4.33.0
+    fastcore>=1.8 # Required for tsai 0.4.1+ compatibility
+    fastai>=2.8 # Required for tsai 0.4.1+ compatibility
+    transformers # Now compatible with latest PyTorch
+    accelerate # Now compatible with latest PyTorch and transformers
 
 
 [options.packages.find]