diff --git a/test/e2e/tests/plots/plots.test.ts b/test/e2e/tests/plots/plots.test.ts
index b450f10e575..646540ee89f 100644
--- a/test/e2e/tests/plots/plots.test.ts
+++ b/test/e2e/tests/plots/plots.test.ts
@@ -188,7 +188,10 @@ test.describe('Plots', { tag: [tags.PLOTS, tags.EDITOR] }, () => {
 			await runScriptAndValidatePlot(app, ipyleaflet, '.leaflet-container');
 		});
 
-		test('Python - Verifies hvplot can load with plotly extension [C766660]', { tag: [tags.WEB, tags.WIN] }, async function ({ app }) {
+		test.skip('Python - Verifies hvplot can load with plotly extension [C766660]', {
+			tag: [tags.WEB, tags.WIN],
+			annotation: [{ type: 'issue', description: 'https://github.com/posit-dev/positron/issues/5991' }],
+		}, async function ({ app }) {
 			await runScriptAndValidatePlot(app, plotly, '.plotly');
 		});