diff --git a/src/selector.rs b/src/selector.rs
index 62550198..6782e805 100644
--- a/src/selector.rs
+++ b/src/selector.rs
@@ -80,7 +80,8 @@ impl<'i> SelectorImpl<'i> for Selectors {
 
   fn to_css<W: fmt::Write>(selectors: &SelectorList<'i>, dest: &mut W) -> std::fmt::Result {
     let mut printer = Printer::new(dest, PrinterOptions::default());
-    serialize_selector_list(selectors.0.iter(), &mut printer, None, false).map_err(|_| std::fmt::Error)
+    serialize_selector_list(selectors.0.iter(), &mut printer, None, false, selectors.0.first())
+      .map_err(|_| std::fmt::Error)
   }
 }
 
@@ -190,6 +191,9 @@ impl<'a, 'o, 'i> parcel_selectors::parser::Parser<'i> for SelectorParser<'a, 'o,
       "corner-present" => WebKitScrollbar(WebKitScrollbarPseudoClass::CornerPresent),
       "window-inactive" => WebKitScrollbar(WebKitScrollbarPseudoClass::WindowInactive),
 
+      "local" if self.options.css_modules.is_some() => LocalNoSelector,
+      "global" if self.options.css_modules.is_some() => GlobalNoSelector,
+
       _ => {
         if !name.starts_with('-') {
           self.options.warn(loc.new_custom_error(SelectorParseErrorKind::UnsupportedPseudoClassOrElement(name.clone())));
@@ -515,6 +519,11 @@ pub enum PseudoClass<'i> {
     selector: Box<Selector<'i>>,
   },
 
+  /// The CSS modules :local selector.
+  LocalNoSelector,
+  /// The CSS modules :global selector.
+  GlobalNoSelector,
+
   /// A [webkit scrollbar](https://webkit.org/blog/363/styling-scrollbars/) pseudo class.
   // https://webkit.org/blog/363/styling-scrollbars/
   #[cfg_attr(
@@ -611,7 +620,7 @@ impl<'i> cssparser::ToCss for PseudoClass<'i> {
     W: fmt::Write,
   {
     let mut s = String::new();
-    serialize_pseudo_class(self, &mut Printer::new(&mut s, Default::default()), None)
+    serialize_pseudo_class(self, &mut Printer::new(&mut s, Default::default()), None, None)
       .map_err(|_| std::fmt::Error)?;
     write!(dest, "{}", s)
   }
@@ -621,6 +630,7 @@ fn serialize_pseudo_class<'a, 'i, W>(
   pseudo_class: &PseudoClass<'i>,
   dest: &mut Printer<W>,
   context: Option<&StyleContext>,
+  nesting: Option<&Selector<'i>>,
 ) -> Result<(), PrinterError>
 where
   W: fmt::Write,
@@ -759,10 +769,29 @@ where
     // https://html.spec.whatwg.org/multipage/semantics-other.html#selector-autofill
     Autofill(prefix) => write_prefixed!(prefix, "autofill"),
 
-    Local { selector } => serialize_selector(selector, dest, context, false),
+    Local { selector } => serialize_selector(selector, dest, context, false, nesting),
     Global { selector } => {
       let css_module = std::mem::take(&mut dest.css_module);
-      serialize_selector(selector, dest, context, false)?;
+      serialize_selector(selector, dest, context, false, nesting)?;
+      dest.css_module = css_module;
+      Ok(())
+    }
+    LocalNoSelector => serialize_selector(
+      &nesting.expect("to_css() does not support :local nor :global"),
+      dest,
+      context,
+      false,
+      nesting,
+    ),
+    GlobalNoSelector => {
+      let css_module = std::mem::take(&mut dest.css_module);
+      serialize_selector(
+        &nesting.expect("to_css() does not support :local nor :global"),
+        dest,
+        context,
+        false,
+        nesting,
+      )?;
       dest.css_module = css_module;
       Ok(())
     }
@@ -1043,16 +1072,17 @@ impl<'i> cssparser::ToCss for PseudoElement<'i> {
     W: fmt::Write,
   {
     let mut s = String::new();
-    serialize_pseudo_element(self, &mut Printer::new(&mut s, Default::default()), None)
+    serialize_pseudo_element(self, &mut Printer::new(&mut s, Default::default()), None, None)
       .map_err(|_| std::fmt::Error)?;
     write!(dest, "{}", s)
   }
 }
 
 fn serialize_pseudo_element<'a, 'i, W>(
-  pseudo_element: &PseudoElement,
+  pseudo_element: &PseudoElement<'i>,
   dest: &mut Printer<W>,
   context: Option<&StyleContext>,
+  css_modules_nesting: Option<&Selector<'i>>,
 ) -> Result<(), PrinterError>
 where
   W: fmt::Write,
@@ -1094,12 +1124,12 @@ where
     CueRegion => dest.write_str("::cue-region"),
     CueFunction { selector } => {
       dest.write_str("::cue(")?;
-      serialize_selector(selector, dest, context, false)?;
+      serialize_selector(selector, dest, context, false, css_modules_nesting)?;
       dest.write_char(')')
     }
     CueRegionFunction { selector } => {
       dest.write_str("::cue-region(")?;
-      serialize_selector(selector, dest, context, false)?;
+      serialize_selector(selector, dest, context, false, css_modules_nesting)?;
       dest.write_char(')')
     }
     Placeholder(prefix) => {
@@ -1253,7 +1283,7 @@ impl<'a, 'i> ToCss for SelectorList<'i> {
   where
     W: fmt::Write,
   {
-    serialize_selector_list(self.0.iter(), dest, dest.context(), false)
+    serialize_selector_list(self.0.iter(), dest, dest.context(), false, self.0.first())
   }
 }
 
@@ -1284,7 +1314,7 @@ impl<'a, 'i> ToCss for Selector<'i> {
   where
     W: fmt::Write,
   {
-    serialize_selector(self, dest, dest.context(), false)
+    serialize_selector(self, dest, dest.context(), false, None)
   }
 }
 
@@ -1293,6 +1323,7 @@ fn serialize_selector<'a, 'i, W>(
   dest: &mut Printer<W>,
   context: Option<&StyleContext>,
   mut is_relative: bool,
+  css_modules_nesting: Option<&Selector<'i>>,
 ) -> Result<(), PrinterError>
 where
   W: fmt::Write,
@@ -1377,7 +1408,7 @@ where
           }
 
           for simple in iter {
-            serialize_component(simple, dest, context)?;
+            serialize_component(simple, dest, context, css_modules_nesting)?;
           }
 
           if swap_nesting {
@@ -1407,15 +1438,15 @@ where
         // This ensures that the compiled selector is valid. e.g. (div.foo is valid, .foodiv is not).
         let nesting = iter.next().unwrap();
         let local = iter.next().unwrap();
-        serialize_component(local, dest, context)?;
+        serialize_component(local, dest, context, css_modules_nesting)?;
 
         // Also check the next item in case of namespaces.
         if first_non_namespace > first_index {
           let local = iter.next().unwrap();
-          serialize_component(local, dest, context)?;
+          serialize_component(local, dest, context, css_modules_nesting)?;
         }
 
-        serialize_component(nesting, dest, context)?;
+        serialize_component(nesting, dest, context, css_modules_nesting)?;
       } else if has_leading_nesting && should_compile_nesting {
         // Nesting selector may serialize differently if it is leading, due to type selectors.
         iter.next();
@@ -1432,7 +1463,7 @@ where
             continue;
           }
         }
-        serialize_component(simple, dest, context)?;
+        serialize_component(simple, dest, context, css_modules_nesting)?;
       }
     }
 
@@ -1457,9 +1488,10 @@ where
 }
 
 fn serialize_component<'a, 'i, W>(
-  component: &Component,
+  component: &Component<'i>,
   dest: &mut Printer<W>,
   context: Option<&StyleContext>,
+  css_modules_nesting: Option<&Selector<'i>>,
 ) -> Result<(), PrinterError>
 where
   W: fmt::Write,
@@ -1510,7 +1542,7 @@ where
         Component::Is(ref selectors) => {
           // If there's only one simple selector, serialize it directly.
           if should_unwrap_is(selectors) {
-            serialize_selector(selectors.first().unwrap(), dest, context, false)?;
+            serialize_selector(selectors.first().unwrap(), dest, context, false, css_modules_nesting)?;
             return Ok(());
           }
 
@@ -1538,16 +1570,16 @@ where
         }
         _ => unreachable!(),
       }
-      serialize_selector_list(list.iter(), dest, context, false)?;
+      serialize_selector_list(list.iter(), dest, context, false, css_modules_nesting)?;
       dest.write_str(")")
     }
     Component::Has(ref list) => {
       dest.write_str(":has(")?;
-      serialize_selector_list(list.iter(), dest, context, true)?;
+      serialize_selector_list(list.iter(), dest, context, true, css_modules_nesting)?;
       dest.write_str(")")
     }
-    Component::NonTSPseudoClass(pseudo) => serialize_pseudo_class(pseudo, dest, context),
-    Component::PseudoElement(pseudo) => serialize_pseudo_element(pseudo, dest, context),
+    Component::NonTSPseudoClass(pseudo) => serialize_pseudo_class(pseudo, dest, context, css_modules_nesting),
+    Component::PseudoElement(pseudo) => serialize_pseudo_element(pseudo, dest, context, css_modules_nesting),
     Component::Nesting => serialize_nesting(dest, context, false),
     Component::Class(ref class) => {
       dest.write_char('.')?;
@@ -1605,10 +1637,10 @@ where
     if ctx.selectors.0.len() == 1
       && (first || (!has_type_selector(&ctx.selectors.0[0]) && is_simple(&ctx.selectors.0[0])))
     {
-      serialize_selector(ctx.selectors.0.first().unwrap(), dest, ctx.parent, false)
+      serialize_selector(ctx.selectors.0.first().unwrap(), dest, ctx.parent, false, None)
     } else {
       dest.write_str(":is(")?;
-      serialize_selector_list(ctx.selectors.0.iter(), dest, ctx.parent, false)?;
+      serialize_selector_list(ctx.selectors.0.iter(), dest, ctx.parent, false, ctx.selectors.0.first())?;
       dest.write_char(')')
     }
   } else {
@@ -1662,6 +1694,7 @@ fn serialize_selector_list<'a, 'i: 'a, I, W>(
   dest: &mut Printer<W>,
   context: Option<&StyleContext>,
   is_relative: bool,
+  nesting: Option<&Selector<'i>>,
 ) -> Result<(), PrinterError>
 where
   I: Iterator<Item = &'a Selector<'i>>,
@@ -1673,7 +1706,7 @@ where
       dest.delim(',', false)?;
     }
     first = false;
-    serialize_selector(selector, dest, context, is_relative)?;
+    serialize_selector(selector, dest, context, is_relative, nesting)?;
   }
   Ok(())
 }
diff --git a/tests/cli_integration_tests.rs b/tests/cli_integration_tests.rs
index 744ac7ca..7906f651 100644
--- a/tests/cli_integration_tests.rs
+++ b/tests/cli_integration_tests.rs
@@ -759,3 +759,59 @@ fn browserslist_environment_from_browserslist_env() -> Result<(), Box<dyn std::e
 
   Ok(())
 }
+
+#[test]
+fn css_modules_pseudo_classes() -> Result<(), Box<dyn std::error::Error>> {
+  let dir = assert_fs::TempDir::new()?;
+  let infile = dir.child("test.css");
+  let outfile = assert_fs::NamedTempFile::new("out.css")?;
+  let modules_file = assert_fs::NamedTempFile::new("module.json")?;
+  infile.write_str(
+    r#"
+      .blue {
+        background: blue;
+
+        :global {
+          .red {
+            background: red;
+          }
+        }
+
+        &:global {
+          &.green {
+            background: green;
+          }
+        }
+      }
+    "#,
+  )?;
+
+  let mut cmd = Command::cargo_bin("lightningcss")?;
+  cmd.current_dir(dir.path());
+  cmd.arg("--targets=defaults");
+  cmd.arg("--nesting");
+  cmd.arg(infile.path());
+  cmd.arg("-o").arg(outfile.path());
+  cmd.arg("--css-modules").arg(modules_file.path());
+  cmd.assert().success();
+
+  outfile.assert(predicate::str::contains(indoc! {r#"
+  .blue {
+      background: blue;
+
+      :global {
+        .red {
+          background: red;
+        }
+      }
+
+      &:global {
+        &.green {
+          background: green;
+        }
+      }
+    }
+"#}));
+
+  Ok(())
+}