diff --git a/lang/python/numpy/Makefile b/lang/python/numpy/Makefile
index bb7539dcca1174..7f948bac884065 100644
--- a/lang/python/numpy/Makefile
+++ b/lang/python/numpy/Makefile
@@ -6,11 +6,11 @@
 include $(TOPDIR)/rules.mk
 
 PKG_NAME:=numpy
-PKG_VERSION:=2.1.3
+PKG_VERSION:=2.2.1
 PKG_RELEASE:=1
 
 PYPI_NAME:=$(PKG_NAME)
-PKG_HASH:=aa08e04e08aaf974d4458def539dece0d28146d866a39da5639596f4921fd761
+PKG_HASH:=45681fd7128c8ad1c379f0ca0776a8b0c6583d2f69889ddac01559dfe4390918
 
 PKG_MAINTAINER:=Alexandru Ardelean <ardeleanalex@gmail.com>
 
@@ -27,9 +27,43 @@ PKG_BUILD_DEPENDS:=python-cython/host pyproject-metadata/host
 PYTHON3_PKG_BUILD_VARS:= \
         $(if $(CONFIG_NUMPY_OPENBLAS_SUPPORT),,NPY_BLAS_ORDER= NPY_LAPACK_ORDER= )
 
+MESON_USE_STAGING_PYTHON:=1
+
 include ../pypi.mk
 include $(INCLUDE_DIR)/package.mk
 include ../python3-package.mk
+include $(INCLUDE_DIR)/meson.mk
+
+MESON_ARGS+= \
+	-Ddisable-optimization=true \
+	-Dcpu-baseline=min
+
+# Override 'Meson', to use numpy's vendored meson
+define Meson
+	$(call Python3/Run,,$(PKG_BUILD_DIR)/vendored-meson/meson/meson.py $(1),$(2))
+endef
+
+define Meson/CreateCrossFile
+	$(STAGING_DIR_HOST)/bin/sed \
+		-e "s|@CC@|$(foreach BIN,$(TARGET_CC),'$(BIN)',)|" \
+		-e "s|@CXX@|$(foreach BIN,$(TARGET_CXX),'$(BIN)',)|" \
+		-e "s|@LD@|$(foreach FLAG,$(TARGET_LINKER),'$(FLAG)',)|" \
+		-e "s|@AR@|$(TARGET_AR)|" \
+		-e "s|@STRIP@|$(TARGET_CROSS)strip|" \
+		-e "s|@NM@|$(TARGET_NM)|" \
+		-e "s|@PKGCONFIG@|$(PKG_CONFIG)|" \
+		-e "s|@CMAKE@|$(STAGING_DIR_HOST)/bin/cmake|" \
+		-e "s|@PYTHON@|$(PYTHON_BIN)|" \
+		-e "s|@CFLAGS@|$(foreach FLAG,$(TARGET_CFLAGS) $(EXTRA_CFLAGS) $(TARGET_CPPFLAGS) $(EXTRA_CPPFLAGS),'$(FLAG)',)|" \
+		-e "s|@CXXFLAGS@|$(foreach FLAG,$(TARGET_CXXFLAGS) $(EXTRA_CXXFLAGS) $(TARGET_CPPFLAGS) $(EXTRA_CPPFLAGS),'$(FLAG)',)|" \
+		-e "s|@LDFLAGS@|$(foreach FLAG,$(TARGET_LDFLAGS) $(EXTRA_LDFLAGS),'$(FLAG)',)|" \
+		-e "s|@ARCH@|$(MESON_ARCH)|" \
+		-e "s|@CPU@|$(MESON_CPU)|" \
+		-e "s|@ENDIAN@|$(if $(CONFIG_BIG_ENDIAN),big,little)|" \
+		< files/openwrt-cross.txt.in \
+		> $(1)
+	echo "longdouble_format = '$(if $(CONFIG_BIG_ENDIAN),IEEE_DOUBLE_BE,IEEE_DOUBLE_LE)'" >> $(1)
+endef
 
 define Package/python3-numpy
   SUBMENU:=Python
@@ -54,12 +88,6 @@ config NUMPY_OPENBLAS_SUPPORT
 endmenu
 endef
 
-ifeq ($(ARCH),x86_64)
-# FIXME: temporary fix for x86_64 with GCC 13 + musl;
-#        numpy does not detect this compiler extension, so we just enable it
-TARGET_CFLAGS += -mavx512f
-endif
-
 define Build/Prepare/numpy-sitecfg
 	echo "[DEFAULT]"                                 >  $(PKG_BUILD_DIR)/site.cfg
 	echo "library_dirs = $(STAGING_DIR)/usr/lib"     >> $(PKG_BUILD_DIR)/site.cfg
diff --git a/lang/python/numpy/files/openwrt-cross.txt.in b/lang/python/numpy/files/openwrt-cross.txt.in
new file mode 100644
index 00000000000000..836a0e51e4fb25
--- /dev/null
+++ b/lang/python/numpy/files/openwrt-cross.txt.in
@@ -0,0 +1,27 @@
+[binaries]
+c = [@CC@]
+c_ld = [@LD@]
+cpp = [@CXX@]
+cpp_ld = [@LD@]
+ar = '@AR@'
+strip = '@STRIP@'
+nm = '@NM@'
+pkg-config = '@PKGCONFIG@'
+cmake = '@CMAKE@'
+python = '@PYTHON@'
+
+[built-in options]
+c_args = [@CFLAGS@]
+c_link_args = [@LDFLAGS@]
+cpp_args = [@CXXFLAGS@]
+cpp_link_args = [@LDFLAGS@]
+prefix = '/usr'
+
+[host_machine]
+system = 'linux'
+cpu_family = '@ARCH@'
+cpu = '@CPU@'
+endian = '@ENDIAN@'
+
+[properties]
+needs_exe_wrapper = true
diff --git a/lang/python/numpy/patches/002-avoid-build-user-config-files.patch b/lang/python/numpy/patches/002-avoid-build-user-config-files.patch
index c3d70207e26269..cf7faf4edc3b6b 100644
--- a/lang/python/numpy/patches/002-avoid-build-user-config-files.patch
+++ b/lang/python/numpy/patches/002-avoid-build-user-config-files.patch
@@ -1,6 +1,6 @@
 --- a/numpy/distutils/system_info.py
 +++ b/numpy/distutils/system_info.py
-@@ -404,7 +404,7 @@ def get_standard_file(fname):
+@@ -403,7 +403,7 @@ def get_standard_file(fname):
          pass
      else:
          user_file = os.path.join(f, fname)
diff --git a/lang/python/numpy/patches/003-without-vendored-meson.patch b/lang/python/numpy/patches/003-without-vendored-meson.patch
deleted file mode 100644
index 3dabd11fa86a3a..00000000000000
--- a/lang/python/numpy/patches/003-without-vendored-meson.patch
+++ /dev/null
@@ -1,34 +0,0 @@
---- a/pyproject.toml
-+++ b/pyproject.toml
-@@ -1,7 +1,7 @@
- [build-system]
--build-backend = "mesonpy"
-+#build-backend = "mesonpy"
- requires = [
--    "meson-python>=0.15.0",
-+#    "meson-python>=0.15.0",
-     "Cython>=3.0.6",  # keep in sync with version check in meson.build
- ]
- 
-@@ -181,8 +181,8 @@ select = "*-win32"
- config-settings = "setup-args=--vsenv setup-args=-Dallow-noblas=true build-dir=build"
- repair-wheel-command = ""
- 
--[tool.meson-python]
--meson = 'vendored-meson/meson/meson.py'
-+#[tool.meson-python]
-+#meson = 'vendored-meson/meson/meson.py'
- 
- [tool.meson-python.args]
- install = ['--tags=runtime,python-runtime,tests,devel']
-@@ -190,8 +190,8 @@ install = ['--tags=runtime,python-runtim
- [tool.spin]
- package = 'numpy'
- 
--[tool.spin.meson]
--cli = 'vendored-meson/meson/meson.py'
-+#[tool.spin.meson]
-+#cli = 'vendored-meson/meson/meson.py'
- 
- [tool.spin.commands]
- "Build" = [
diff --git a/lang/python/numpy/patches/004-workaround-for-multiple-top-level-packages-discovered.patch b/lang/python/numpy/patches/004-workaround-for-multiple-top-level-packages-discovered.patch
deleted file mode 100644
index c5424b50c97e93..00000000000000
--- a/lang/python/numpy/patches/004-workaround-for-multiple-top-level-packages-discovered.patch
+++ /dev/null
@@ -1,12 +0,0 @@
---- a/pyproject.toml
-+++ b/pyproject.toml
-@@ -59,6 +59,9 @@ download = "https://pypi.org/project/num
- tracker = "https://github.com/numpy/numpy/issues"
- "release notes" = "https://numpy.org/doc/stable/release"
- 
-+[tool.setuptools]
-+py-modules = []
-+
- [tool.towncrier]
-     single_file = false
-     filename = "doc/source/release/notes-towncrier.rst"
diff --git a/lang/python/numpy/test.sh b/lang/python/numpy/test.sh
new file mode 100644
index 00000000000000..dc22892ca49d85
--- /dev/null
+++ b/lang/python/numpy/test.sh
@@ -0,0 +1,18 @@
+#!/bin/sh
+
+EXP_VER="$2"
+
+python3 - << EOF
+import sys
+import numpy as np
+
+if (np.__version__ != "$EXP_VER"):
+    print("Got incorrect version: " + np.__version__)
+    sys.exit(1)
+
+arr = np.array([1, 2, 3, 4, 5])
+
+print(arr)
+
+EOF
+