Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Docs for different methods to annotate AA muts #189

Open
joverlee521 opened this issue Feb 8, 2024 · 2 comments
Open

Docs for different methods to annotate AA muts #189

joverlee521 opened this issue Feb 8, 2024 · 2 comments
Labels
documentation Improvements or additions to documentation

Comments

@joverlee521
Copy link
Contributor

We currently have two methods for annotating AA muts.

  1. The traditional path explained in the Creating a pathogen workflow tutorial uses augur ancestral for NT muts and augur translate for AA muts.
  2. The new feature to allow augur ancestral to reconstruct AA muts

We should have docs to compare the two method to annotate the AA muts with suggestions on when to use each method.
This should also point to existing repos as examples that use each method.

@joverlee521 joverlee521 added the documentation Improvements or additions to documentation label Feb 8, 2024
@jameshadfield
Copy link
Member

This would be great. The major differences I see are that (1) has worse AA alignments due to gap placement, but the AAs are always 1-1 with the nucleotide mutations whereas (2) has better AA alignments but loses the relationship between nuc mutations and corresponding AA mutations, as shown in Auspice.

@jameshadfield
Copy link
Member

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
documentation Improvements or additions to documentation
Projects
None yet
Development

No branches or pull requests

2 participants