diff --git a/onnxruntime/test/contrib_ops/matmul_2bits_test.cc b/onnxruntime/test/contrib_ops/matmul_2bits_test.cc
index 1837c1f4ffa7f..853458312cd1f 100644
--- a/onnxruntime/test/contrib_ops/matmul_2bits_test.cc
+++ b/onnxruntime/test/contrib_ops/matmul_2bits_test.cc
@@ -371,7 +371,8 @@ TEST(MatMulNBitsLutGemm, Float32_2Bits_Symmetric_256x256) {
   TestMatMul2BitsLutGemm<float>(1, 256, 256, 32, false);
 }
 
-TEST(MatMulNBitsLutGemm, Float32_2Bits_Asymmetric_256x256) {
+// TODO: Re-enable once LUT GEMM asymmetric quantization accuracy issue is resolved
+TEST(MatMulNBitsLutGemm, DISABLED_Float32_2Bits_Asymmetric_256x256) {
   TestMatMul2BitsLutGemm<float>(1, 256, 256, 32, true);
 }