When Metalama.Framework.Engine is compiled using Metalama.Compiler that merged Roslyn 4.8.0-2.final, it triggers Debug.Assert in Roslyn's Compilers\CSharp\Portable\FlowAnalysis\NullableWalker.cs (specifically, Debug.Assert(_targetTypedAnalysisCompletionOpt is null or { Count: 0 }); in NullableWalker.Free()).
This should be investigated and potentially reported to Roslyn.