Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Output reads not paired with a mixture of single end and paired end reads when using smart-pairing #403

Open
nh13 opened this issue Oct 6, 2023 · 0 comments

Comments

@nh13
Copy link
Contributor

nh13 commented Oct 6, 2023

If there is an odd number of single end reads in the first chunk read in by bwa, then potentially paired end reads in subsequent blocks may not have their pair flag set.

BWA reads in a fixed # of individual records, THEN checks for pairing, so if a paired end read spans the chunk boundary, they wont be paired.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant