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Support other gene identifiers #7

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j-andrews7 opened this issue Apr 18, 2024 · 2 comments
Open

Support other gene identifiers #7

j-andrews7 opened this issue Apr 18, 2024 · 2 comments

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@j-andrews7
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Gene symbols are fickle beasts and subject to change. Support for converting other identifiers (Entrez, Ensembl) to their gene symbol on the fly would be ideal, as I know the GO annotations themselves prefer the symbol be used.

@j-andrews7 j-andrews7 mentioned this issue Apr 18, 2024
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@ialbert
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ialbert commented Apr 18, 2024

Here the issue is that this tool works off gene ontology data. We build upon of what they publish and how they chose to map a symbol to a gene ontology. We use the symbols the Gene Ontology Consortium selected to annotate the data.

I also hate converting between gene ids, but it is not tools like this where we need to demand that gene id conversion happens automatically.

These conversions should happen much earlier via authoritative processes where we know there is ongoing oversight that the mappings are correct and most up to date.

By the time someone needs a tool like GeneScape they should have a table where the genes are mapped to GO symbols as well. The GeneScape symbols are in my opinion the closest to how biologists think about problems as these symbols have names that relate to functions.

@ialbert
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ialbert commented Apr 22, 2024

I could not make the additional symbols work, but I have added three more genomes by default and now the system includes, human, mouse, rat, drosophila and zebrafisth

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