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updates to the paper
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docs/paper.md

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@@ -37,7 +37,7 @@ The [Gene Ontology Consortium][GO] maintains GAF files for various organisms. Ty
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The most annotated gene in the human genome, `HTT`, currently has 1100 annotations. Thus, even small lists of genes may have a large number of annotations presenting an extraordinary challenge for interpretation. There is a clear need to visualize shared gene functions in an informative manner.
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Web-based tools designed to visualize and filter gene ontology data include `AmiGO` [@AmiGO] and `QuickGO` [@QuickGO]. Command line tools like `goatools` [@goatools] support GO term lineage visualization. R packages like `topGO` [@topGO] implement GO structure visualizations of enriched GO terms. We are unaware of locally installable software that specifically allows for interactive filtering and visualization of gene ontology derived on gene lists.
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Web-based tools designed to visualize and filter gene ontology data include `AmiGO` [@AmiGO] and `QuickGO` [@QuickGO]. Command line tools like `goatools` [@goatools] support GO term lineage visualization. R packages like `topGO` [@topGO] implement GO structure visualizations of enriched GO terms. We are unaware of locally installable software that allows for interactive filtering and visualization of gene ontology terms derived from gene lists.
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GeneScape is a Python package that allows users to visualize a list of genes in the functional context represented by the Gene Ontology
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Users can reduce the tree to show only terms that match the word `lipid` and with at least two genes supporting the function via the graphical user interface or the command line:
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```console
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genescape tree -m lipid --micov 2 genes2.txt -o output.pdf
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genescape tree -m lipid --mincov 2 genes2.txt -o output.pdf
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```
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The filtering process will result in a smaller tree with 18 nodes and 29 edges, focused on the functions that contain the word "lipid":

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