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Welcome to the Lentivirus-GLUE User Guide!
Lentivirus-GLUE is a specialized resource designed to support comparative genomic and evolutionary analysis of lentiviruses, developed using the GLUE framework. Lentiviruses are complex retroviruses that cause chronic diseases in humans and animals, with HIV-1 being the most well-known example.
This resource leverages the GLUE software framework, providing an efficient, standardized platform for analyzing viral genomes. By integrating sequences, annotations, and relational data into a comprehensive, extensible system, Lentivirus-GLUE facilitates advanced computational analysis, reducing the need for manual data handling and enabling researchers to focus on scientific discovery.
- Comprehensive Genomic Database: Lentivirus-GLUE integrates data from all known lentivirus sequences, providing a robust foundation for comparative genomics research.
- Standardized Data Formats: All genomic data, including sequences, alignments, and annotations, are standardized, ensuring consistency and interoperability across analyses.
- Relational Data Structure: The GLUE framework links sequences with complex metadata, allowing for rich, context-driven queries and analyses while minimizing manual pre-processing of datasets.
- Customizable Comparative Genomics Tools: Researchers can perform customizable genomic analyses, such as evolutionary studies, phylogenetic reconstruction, and genome feature comparisons, tailored to their specific research questions.
- Extensible Platform: The resource is highly extensible, allowing users to add their own data, annotations, and custom analysis tools, seamlessly integrating them into the core system.
- Reproducible Workflows Designed to ensure reproducibility, Lentivirus-GLUE enables users to save and share their analyses, allowing for collaboration and transparent research practices.
To begin using Lentivirus-GLUE for comparative genomic analysis, you can choose between:
- Docker-based installation for ease of deployment.
- Native installation for traditional setup.
Lentivirus-GLUE projects can be installed as prebuilt databases for quick setup, or constructed from scratch for more customization.