DESCRIPTION

Package: precautionary
Type: Package
Title: Safety Diagnostics for Dose-Escalation Trial Designs
Version: 0.2.6-1
Date: 2021-08-14
Authors@R: c(person("David C.", "Norris"
                   , role = c("aut", "cre", "cph")
                   , email = "david@precisionmethods.guru"
                   , comment = c(ORCID = "0000-0001-9593-6343")
                   ),
             person("Markus", "Triska"
                   , role = "ctb"
                   , email = "triska@metalevel.at"
                   )
            )
Maintainer: David C. Norris <david@precisionmethods.guru>
Depends: 
    magrittr,
    escalation,
    data.table,
    R6,
    R (>= 4.0.0)
Imports: methods, dplyr, rlang, stringr, knitr, kableExtra, microbenchmark, dfcrm, BOIN,
	 parallelly, utils
Suggests: 
    dtpcrm,
    rmarkdown,
    bookdown,
    tufte,
    testthat,
    lattice,
    latticeExtra,
    shiny,
    shinyjs,
    shinyFeedback
Description: Enhances various R packages that support the design and simulation
             of phase 1 dose-escalation trials, adding diagnostics to examine
             the safety characteristics of these designs in light of expected
             inter-individual variation in pharmacokinetics and pharmacodynamics.
             See Norris (2020b), "Retrospective analysis of a fatal dose-finding
             trial" <arXiv:2004.12755> and (2020c) "What Were They Thinking?
             Pharmacologic priors implicit in a choice of 3+3 dose-escalation design"
             <arXiv:2012.05301>.
URL: https://github.com/dcnorris/precautionary
License: MIT + file LICENSE
Roxygen: list(markdown = TRUE)
VignetteBuilder: knitr, rmarkdown
Encoding: UTF-8
NeedsCompilation: yes
OS_type: unix
SystemRequirements: Cargo (rustc package manager)
RoxygenNote: 7.1.1
Collate:
    'bench.R'
    'boin.R'
    'ccd.R'
    'cpe.R'
    'crm.R'
    'data.R'
    'dtp.R'
    'dutycycle.R'
    'enhance.R'
    'exact.R'
    'extendr-wrappers.R'
    'hyperprior.R'
    'mclapply.R'
    'precautionary-package.R'
    'toxicity_generators.R'
    'simulate_trials.R'
    'three3.R'
LazyData: true
ByteCompile: true
Config/testthat/edition: 3
BugReports: https://github.com/dcnorris/precautionary/issues