diff --git a/miasm/core/asmblock.py b/miasm/core/asmblock.py
index f412de869..a0fee580d 100644
--- a/miasm/core/asmblock.py
+++ b/miasm/core/asmblock.py
@@ -623,6 +623,11 @@ def sanity_check(self):
         for loc_key in self._nodes:
             if loc_key not in self._loc_key_to_block:
                 raise RuntimeError("Not supported yet: every node must have a corresponding AsmBlock")
+
+            block = self.loc_key_to_block(loc_key)
+            if not block.lines and not isinstance(block, AsmBlockBad):
+                raise RuntimeError("Blocks cannot be empty")
+
             # No next constraint to self
             if (loc_key, loc_key) in next_edges:
                 raise RuntimeError('Bad constraint: self in next')
diff --git a/test/core/asmblock.py b/test/core/asmblock.py
index 47f925690..2ab562185 100644
--- a/test/core/asmblock.py
+++ b/test/core/asmblock.py
@@ -139,6 +139,13 @@ def remove_useless_blocks(d_g, graph):
 assert len(list(asmcfg.get_bad_blocks_predecessors(strict=True))) == 0
 
 ## Sanity check
+flag = False
+try:
+    asmcfg.sanity_check()
+except RuntimeError:
+    flag = True
+assert flag
+my_block.lines = [first_block.lines[0]]
 asmcfg.sanity_check()
 ### Next on itself
 testlabel_nextitself = mdis.loc_db.get_or_create_name_location("testlabel_nextitself")