diff --git a/miasm/core/asmblock.py b/miasm/core/asmblock.py
index 93ad6b132..1e85938f5 100644
--- a/miasm/core/asmblock.py
+++ b/miasm/core/asmblock.py
@@ -729,6 +729,10 @@ def sanity_check(self):
         for loc_key in self._nodes:
             if loc_key not in self._loc_key_to_block:
                 raise RuntimeError("Not supported yet: every node must have a corresponding AsmBlock")
+            
+            if not self.loc_key_to_block(loc_key).lines:
+                raise RuntimeError("Blocks cannot be empty")
+            
             # No next constraint to self
             if (loc_key, loc_key) in next_edges:
                 raise RuntimeError('Bad constraint: self in next')