diff --git a/CMakeLists.txt b/CMakeLists.txt
index 2c2beb112c3..4b21646ca18 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -438,8 +438,16 @@ configure_file(contrib/filter-lcov.py filter-lcov.py USE_SOURCE_PERMISSIONS COPY
 # Don't allow extended (non-ASCII) symbols in identifiers. This is easier for code review.
 try_append_cxx_flags("-fno-extended-identifiers" TARGET core_interface SKIP_LINK)
 
-try_append_cxx_flags("-ffile-prefix-map=A=B" TARGET core_interface SKIP_LINK
-  IF_CHECK_PASSED "-ffile-prefix-map=${PROJECT_SOURCE_DIR}/src=."
+# Avoiding the `-ffile-prefix-map` compiler option because it implies
+# `-fcoverage-prefix-map` on Clang or `-fprofile-prefix-map` on GCC,
+# which can cause issues with coverage builds, particularly when using
+# Clang in the OSS-Fuzz environment due to its use of other options
+# and a third party script, or with GCC.
+try_append_cxx_flags("-fdebug-prefix-map=A=B" TARGET core_interface SKIP_LINK
+  IF_CHECK_PASSED "-fdebug-prefix-map=${PROJECT_SOURCE_DIR}/src=."
+)
+try_append_cxx_flags("-fmacro-prefix-map=A=B" TARGET core_interface SKIP_LINK
+  IF_CHECK_PASSED "-fmacro-prefix-map=${PROJECT_SOURCE_DIR}/src=."
 )
 
 # Currently all versions of gcc are subject to a class of bugs, see the