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1 | 1 | # metamodel_version: 1.7.0
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2 |
| -# version: 4.2.5 |
| 2 | +# version: 4.2.6-rc5 |
| 3 | +enum AgentTypeEnum |
| 4 | + { |
| 5 | + manual_agent |
| 6 | + automated_agent |
| 7 | + data_analysis_pipeline |
| 8 | + computational_model |
| 9 | + text_mining_agent |
| 10 | + image_processing_agent |
| 11 | + manual_validation_of_automated_agent |
| 12 | + not_provided |
| 13 | + } |
| 14 | + |
| 15 | +enum ApprovalStatusEnum |
| 16 | + { |
| 17 | + discovery_and_development_phase |
| 18 | + preclinical_research_phase |
| 19 | + fda_clinical_research_phase |
| 20 | + fda_review_phase_4 |
| 21 | + fda_post_market_safety_review |
| 22 | + fda_clinical_research_phase_1 |
| 23 | + fda_clinical_research_phase_2 |
| 24 | + fda_clinical_research_phase_3 |
| 25 | + fda_clinical_research_phase_4 |
| 26 | + fda_fast_track |
| 27 | + fda_breakthrough_therapy |
| 28 | + fda_accelerated_approval |
| 29 | + fda_priority_review |
| 30 | + regular_fda_approval |
| 31 | + post_approval_withdrawal |
| 32 | + } |
| 33 | + |
| 34 | +enum CausalMechanismQualifierEnum |
| 35 | + { |
| 36 | + binding |
| 37 | + inhibition |
| 38 | + antibody_inhibition |
| 39 | + antagonism |
| 40 | + molecular_channel_blockage |
| 41 | + inverse_agonism |
| 42 | + negative_allosteric_modulation |
| 43 | + agonism |
| 44 | + molecular_channel_opening |
| 45 | + positive_allosteric_modulation |
| 46 | + potentiation |
| 47 | + activation |
| 48 | + inducer |
| 49 | + transcriptional_regulation |
| 50 | + signaling_mediated_control |
| 51 | + stabilization |
| 52 | + stimulation |
| 53 | + releasing_activity |
| 54 | + } |
| 55 | + |
| 56 | +enum ChemicalEntityDerivativeEnum |
| 57 | + { |
| 58 | + metabolite |
| 59 | + } |
| 60 | + |
| 61 | +enum ChemicalOrGeneOrGeneProductFormOrVariantEnum |
| 62 | + { |
| 63 | + genetic_variant_form |
| 64 | + modified_form |
| 65 | + loss_of_function_variant_form |
| 66 | + gain_of_function_variant_form |
| 67 | + polymorphic_form |
| 68 | + snp_form |
| 69 | + analog_form |
| 70 | + } |
| 71 | + |
| 72 | +enum ClinicalApprovalStatusEnum |
| 73 | + { |
| 74 | + approved_for_condition |
| 75 | + fda_approved_for_condition |
| 76 | + not_approved_for_condition |
| 77 | + post_approval_withdrawal |
| 78 | + off_label_use |
| 79 | + not_provided |
| 80 | + } |
| 81 | + |
| 82 | +enum DirectionQualifierEnum |
| 83 | + { |
| 84 | + increased |
| 85 | + upregulated |
| 86 | + decreased |
| 87 | + downregulated |
| 88 | + } |
| 89 | + |
| 90 | +enum DrugAvailabilityEnum |
| 91 | + { |
| 92 | + over_the_counter |
| 93 | + prescription |
| 94 | + } |
| 95 | + |
| 96 | +enum DrugDeliveryEnum |
| 97 | + { |
| 98 | + inhalation |
| 99 | + oral |
| 100 | + absorption_through_the_skin |
| 101 | + intravenous_injection |
| 102 | + } |
| 103 | + |
| 104 | +enum DruggableGeneCategoryEnum |
| 105 | + { |
| 106 | + tclin |
| 107 | + tbio |
| 108 | + tchem |
| 109 | + tdark |
| 110 | + } |
| 111 | + |
| 112 | +enum FDAIDAAdverseEventEnum |
| 113 | + { |
| 114 | + life_threatening_adverse_event |
| 115 | + serious_adverse_event |
| 116 | + suspected_adverse_reaction |
| 117 | + unexpected_adverse_event |
| 118 | + } |
| 119 | + |
| 120 | +enum GeneOrGeneProductOrChemicalEntityAspectEnum |
| 121 | + { |
| 122 | + activity_or_abundance |
| 123 | + abundance |
| 124 | + activity |
| 125 | + expression |
| 126 | + synthesis |
| 127 | + degradation |
| 128 | + cleavage |
| 129 | + hydrolysis |
| 130 | + metabolic_processing |
| 131 | + mutation_rate |
| 132 | + stability |
| 133 | + folding |
| 134 | + localization |
| 135 | + transport |
| 136 | + absorption |
| 137 | + aggregation |
| 138 | + interaction |
| 139 | + release |
| 140 | + secretion |
| 141 | + uptake |
| 142 | + splicing |
| 143 | + molecular_interaction |
| 144 | + guanyl_nucleotide_exchange |
| 145 | + adenyl_nucleotide_exchange |
| 146 | + molecular_modification |
| 147 | + acetylation |
| 148 | + acylation |
| 149 | + alkylation |
| 150 | + amination |
| 151 | + carbamoylation |
| 152 | + ethylation |
| 153 | + glutathionylation |
| 154 | + glycation |
| 155 | + glycosylation |
| 156 | + glucuronidation |
| 157 | + n_linked_glycosylation |
| 158 | + o_linked_glycosylation |
| 159 | + hydroxylation |
| 160 | + lipidation |
| 161 | + farnesylation |
| 162 | + geranoylation |
| 163 | + myristoylation |
| 164 | + palmitoylation |
| 165 | + prenylation |
| 166 | + methylation |
| 167 | + nitrosation |
| 168 | + nucleotidylation |
| 169 | + phosphorylation |
| 170 | + ribosylation |
| 171 | + ADP__HYPHEN_MINUS__ribosylation |
| 172 | + sulfation |
| 173 | + sumoylation |
| 174 | + ubiquitination |
| 175 | + oxidation |
| 176 | + reduction |
| 177 | + carboxylation |
| 178 | + } |
| 179 | + |
| 180 | +enum GeneOrGeneProductOrChemicalPartQualifierEnum |
| 181 | + { |
| 182 | + __3_prime_utr |
| 183 | + __5_prime_utr |
| 184 | + polya_tail |
| 185 | + promoter |
| 186 | + enhancer |
| 187 | + exon |
| 188 | + intron |
| 189 | + } |
| 190 | + |
| 191 | +enum KnowledgeLevelEnum |
| 192 | + { |
| 193 | + knowledge_assertion |
| 194 | + logical_entailment |
| 195 | + prediction |
| 196 | + statistical_association |
| 197 | + observation |
| 198 | + not_provided |
| 199 | + } |
| 200 | + |
| 201 | +enum LogicalInterpretationEnum |
| 202 | + { |
| 203 | + some_some |
| 204 | + all_some |
| 205 | + inverse_all_some |
| 206 | + } |
| 207 | + |
| 208 | +enum PhaseEnum |
| 209 | + { |
| 210 | + __0 |
| 211 | + __1 |
| 212 | + __2 |
| 213 | + } |
| 214 | + |
| 215 | +enum ReactionDirectionEnum |
| 216 | + { |
| 217 | + left_to_right |
| 218 | + right_to_left |
| 219 | + bidirectional |
| 220 | + neutral |
| 221 | + } |
| 222 | + |
| 223 | +enum ReactionSideEnum |
| 224 | + { |
| 225 | + left |
| 226 | + right |
| 227 | + } |
| 228 | + |
| 229 | +enum ResearchPhaseEnum |
| 230 | + { |
| 231 | + pre_clinical_research_phase |
| 232 | + clinical_trial_phase |
| 233 | + clinical_trial_phase_1 |
| 234 | + clinical_trial_phase_2 |
| 235 | + clinical_trial_phase_3 |
| 236 | + clinical_trial_phase_4 |
| 237 | + not_provided |
| 238 | + } |
| 239 | + |
| 240 | +enum ResourceRoleEnum |
| 241 | + { |
| 242 | + primary_knowledge_source |
| 243 | + aggregator_knowledge_source |
| 244 | + supporting_data_source |
| 245 | + } |
| 246 | + |
| 247 | +enum SequenceEnum |
| 248 | + { |
| 249 | + na |
| 250 | + aa |
| 251 | + } |
| 252 | + |
| 253 | +enum StrandEnum |
| 254 | + { |
| 255 | + __PLUS_SIGN__ |
| 256 | + __HYPHEN_MINUS__ |
| 257 | + __FULL_STOP__ |
| 258 | + __QUESTION_MARK__ |
| 259 | + } |
| 260 | + |
3 | 261 | type AccessibleDnaRegion implements GenomicEntity, ChemicalEntityOrGeneOrGeneProduct, PhysicalEssence, OntologyClass
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4 | 262 | {
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5 | 263 | id: String!
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