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Comet MS/MS

Comet is an open source tandem mass spectrometry (MS/MS) sequence database search tool written primarily in C/C++. The original Comet repository lived on SourceForge since 2012. It was migrated to GitHub on September 2021.

The project website can be found here. This includes release notes and search parameters documentation.

To compile on linux and macOS:

  • Type 'make'. This will generate a binary "comet.exe".

To compile with Microsoft Visual Studio:

  • Use build tools v142 with Microsoft Visual Studio 2019.

  • First install MSFileReader from Thermo Fischer Scientific.

  • Load "Comet.sln" in Visual Studio.

  • Set the build to "Release" and "x64".

  • Right-mouse-click on the "Comet" project and choose "Build". This should generate a binary "Comet.exe" in x64/Release.