diff --git a/base/loading.jl b/base/loading.jl
index 9137651007c30a..7d92c19c461458 100644
--- a/base/loading.jl
+++ b/base/loading.jl
@@ -2645,6 +2645,7 @@ end
                     return true
                 end
             end
+            tracked_path = unsafe_string(JLOptions().tracked_path)
             for chi in includes
                 f, ftime_req = chi.filename, chi.mtime
                 if !isfile(f)
@@ -2657,6 +2658,14 @@ end
                     @debug "Rejecting stale cache file $cachefile because file $f does not exist"
                     return true
                 end
+                if JLOptions().code_coverage == 3 && occursin(tracked_path, f)
+                    @debug "Rejecting cache file $cachefile because included file $f is being tracked by --code-coverage"
+                    return true
+                end
+                if JLOptions().malloc_log == 3 && occursin(tracked_path, f)
+                    @debug "Rejecting cache file $cachefile because included file $f is being tracked by --track-allocation"
+                    return true
+                end
                 ftime = mtime(f)
                 is_stale = ( ftime != ftime_req ) &&
                            ( ftime != floor(ftime_req) ) &&           # Issue #13606, PR #13613: compensate for Docker images rounding mtimes