README.rst

NAFLD - multimorbidy analysis

This repository contains data, analysis and visualization scripts used for the preparation of the manuscript - Deciphering the genetic links between NAFLD and co-occurring conditions using a liver gene regulatory network. Here, we constructed a liver-specific gene regulatory network consisting of genome-wide spatially constrained expression quantitative trait loci (eQTL) and their target genes, which was used to investigate shared genetic mechanisms underlying NAFLD multimorbidities.

References

[1]	Fadason, T., Schierding, W., Lumley, T., & O’Sullivan, J. M. (2018). Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities. Nature Communications, 9(1), 1–13. https://doi.org/10.1038/s41467-018-07692-y

[2]	Aguet, F., Barbeira, A. N., Bonazzola, R., Jo, B., Kasela, S., Liang, Y., … Wen, X. (2020). The GTEx Consortium atlas of genetic regulatory effects across human tissues. Science, 369(6509), 1318–1330. https://doi.org/10.1126/science.aaz1776